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 » Research Center for Pharmaceutical Nanotechnology, Research and Development Complex, Tabriz University of Medical Sciences, Daneshgah street, Tabriz, IRAN. Postal Code: 5165665811

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  Gene delivery nanosystems and cell therapy

Technical approach

Research leader

Research assistants

Post-doc researchers


Selected publications

Gene delivery nanosystems and cell therapy

Over the past three decades, the continuous culture of eukaryotic cells has become a mainstay technique in many different forms of biological, biochemical, and biomedical experimentation. Researchers in cell and tissue engineering lab of RCPN maintain the first step of cutting age tests and adaptation of research findings on eukaryotic cells and cell lines. Thus this section supports projects in many aspects of the pharmaceutical sciences and is used by all the scientific research groups in the RCPN. Use of cell culture enables studies to be conducted with human cells and therefore minimizes the necessity for experiments on animals.


Technical approach

Cell cultures & Tissue engineering
Microscopy & Micro analysis

Research Leader

Dr. Mohammad hossein Geranmaye ,(M.Sc, Ph.D)
Prof. Jaleh Barar, (PharmD, Ph.D)
Dr. Aylar Nakhlband (M.Sc, Ph.D)
Prof. Yadollah Omidi, (PharmD, Ph.D)


Research Assistants
Asal golchin
Nazli saeidi


Post-doc researchers

Will be updated ASAP.



Will be updated as soon as possible!

Selected Publication based on scopus

Lats two years publications (2017-2018)

1.            Abdollahi-Aghdam A, Majidi MR, Omidi Y. Microfluidic paper-based analytical devices (µPADs) for fast and ultrasensitive sensing of biomarkers and monitoring of diseases. BioImpacts. 2018;8(4):237-40.

2.            Aghanejad A, Babamiri H, Adibkia K, Barar J, Omidi Y. Mucin-1 aptamer-armed superparamagnetic iron oxide nanoparticles for targeted delivery of doxorubicin to breast cancer cells. BioImpacts. 2018;8(2):117-27.

3.            Akbari Nakhjavani S, Khalilzadeh B, Samadi Pakchin P, Saber R, Ghahremani MH, Omidi Y. A highly sensitive and reliable detection of CA15-3 in patient plasma with electrochemical biosensor labeled with magnetic beads. Biosensors and Bioelectronics. 2018;122:8-15.

4.            Arteshi Y, Aghanejad A, Davaran S, Omidi Y. Biocompatible and electroconductive polyaniline-based biomaterials for electrical stimulation. European Polymer Journal. 2018;108:150-70.

5.            Asghari S, Movafeghi A, Lisar SYS, Barar J, Omidi Y. Effects of phenanthrene on growth parameters and antioxidant systems in the green microalga chlorella vulgaris. Biointerface Research in Applied Chemistry. 2018;8(4):3405-11.

6.            Asgharzadeh MR, Barar J, Pourseif MM, Eskandani M, Niya MJ, Mashayekhi MR, et al. Molecular machineries of pH dysregulation in tumor microenvironment: Potential targets for cancer therapy. BioImpacts. 2017;7(2):115-33.

7.            Asoudeh-Fard A, Barzegari A, Dehnad A, Bastani S, Golchin A, Omidi Y. Lactobacillus plantarum induces apoptosis in oral cancer KB cells through upregulation of PTEN and downregulation of MAPK signaling pathways. BioImpacts. 2017;7(3):193-8.

8.            Bakhtiary Z, Barar J, Aghanejad A, Saei AA, Nemati E, Ezzati Nazhad Dolatabadi J, et al. Microparticles containing erlotinib-loaded solid lipid nanoparticles for treatment of non-small cell lung cancer. Drug Development and Industrial Pharmacy. 2017;43(8):1244-53.

9.            Borran AA, Aghanejad A, Farajollahi A, Barar J, Omidi Y. Gold nanoparticles for radiosensitizing and imaging of cancer cells. Radiation Physics and Chemistry. 2018;152:137-44.

10.          Daryanoosh M, Goudarzi G, Rashidi R, Keishams F, Hopke PK, Mohammadi MJ, et al. Risk of morbidity attributed to ambient PM<inf>10</inf>in the western cities of Iran. Toxin Reviews. 2017:1-6.

11.          Dehghani J, Adibkia K, Movafeghi A, Barzegari A, Pourseif MM, Maleki Kakelar H, et al. Stable transformation of Spirulina (Arthrospira) platensis: a promising microalga for production of edible vaccines. Applied Microbiology and Biotechnology. 2018;102(21):9267-78.

12.          Eskandani M, Vandghanooni S, Barar J, Nazemiyeh H, Omidi Y. Cell physiology regulation by hypoxia inducible factor-1: Targeting oxygen-related nanomachineries of hypoxic cells. International Journal of Biological Macromolecules. 2017;99:46-62.

13.          Fahimi F, Sarhaddi S, Fouladi M, Samadi N, Sadeghi J, Golchin A, et al. Phage display-derived antibody fragments against conserved regions of VacA toxin of Helicobacter pylori. Applied Microbiology and Biotechnology. 2018;102(16):6899-913.

14.          Fahimi F, Tohidkia MR, Fouladi M, Aqabeigi R, Samadi N, Omidi Y. Pleiotropic cytotoxicity of VacA toxin in host cells and its impact on immunotherapy. BioImpacts. 2017;7(1):59-71.

15.          Fathi M, Majidi S, Zangabad PS, Barar J, Erfan-Niya H, Omidi Y. Chitosan-based multifunctional nanomedicines and theranostics for targeted therapy of cancer. Medicinal Research Reviews. 2018;38(6):2110-36.

16.          Fathi M, Sahandi Zangabad P, Barar J, Aghanejad A, Erfan-Niya H, Omidi Y. Thermo-sensitive chitosan copolymer-gold hybrid nanoparticles as a nanocarrier for delivery of erlotinib. International Journal of Biological Macromolecules. 2018;106:266-76.

17.          Fathi M, Zangabad PS, Aghanejad A, Barar J, Erfan-Niya H, Omidi Y. Folate-conjugated thermosensitive O-maleoyl modified chitosan micellar nanoparticles for targeted delivery of erlotinib. Carbohydrate Polymers. 2017;172:130-41.

18.          Fathi M, Zangabad PS, Majidi S, Barar J, Erfan-Niya H, Omidi Y. Stimuli-responsive chitosan-based nanocarriers for cancer therapy. BioImpacts. 2017;7(4):269-77.

19.          Ferdousi R, Safdari R, Omidi Y. Computational prediction of drug-drug interactions based on drugs functional similarities. Journal of Biomedical Informatics. 2017;70:54-64.

20.          Gharaati-Far N, Tohidkia MR, Dehnad A, Omidi Y. Efficiency and cytotoxicity analysis of cationic lipids-mediated gene transfection into AGS gastric cancer cells. Artificial Cells, Nanomedicine and Biotechnology. 2018;46(5):1001-8.

21.          Goudarzi G, Daryanoosh SM, Godini H, Hopke PK, Sicard P, De Marco A, et al. Health risk assessment of exposure to the Middle-Eastern Dust storms in the Iranian megacity of Kermanshah. Public Health. 2017;148:109-16.

22.          Jafarizad A, Aghanejad A, Sevim M, Metin Ö, Barar J, Omidi Y, et al. Gold Nanoparticles and Reduced Graphene Oxide-Gold Nanoparticle Composite Materials as Covalent Drug Delivery Systems for Breast Cancer Treatment. ChemistrySelect. 2017;2(23):6663-72.

23.          Karami P, Majidi MR, Johari-Ahar M, Barar J, Omidi Y. Development of screen-printed tryptophan-kynurenine immunosensor for in vitro assay of kynurenine-mediated immunosuppression effect of cancer cells on activated T-cells. Biosensors and Bioelectronics. 2017;92:287-93.

24.          Khajeh S, Tohidkia MR, Aghanejad A, Mehdipour T, Fathi F, Omidi Y. Phage display selection of fully human antibody fragments to inhibit growth-promoting effects of glycine-extended gastrin 17 on human colorectal cancer cells. Artificial Cells, Nanomedicine and Biotechnology. 2018:1-9.

25.          Maleki Kakelar H, Barzegari A, Dehghani J, Hanifian S, Saeedi N, Barar J, et al. Pathogenicity of Helicobacter pylori in cancer development and impacts of vaccination. Gastric Cancer. 2018.

26.          Mesgari-Shadi A, Sarrafzadeh MH, Barar J, Omidi Y. Cost-effective batch production process of scFv antibody in Escherichia coli. Human Antibodies. 2017;26(3):149-57.

27.          Mesgari-Shadi A, Sarrafzadeh MH, Divband B, Barar J, Omidi Y. Batch adsorption/desorption for purification of scFv antibodies using nanozeolite microspheres. Microporous and Mesoporous Materials. 2018;264:167-75.

28.          Mohammadi MJ, Yari AR, Saghazadeh M, Sobhanardakani S, Geravandi S, Afkar A, et al. A health risk assessment of heavy metals in people consuming Sohan in Qom, Iran. Toxin Reviews. 2017:1-9.

29.          Momtazan M, Geravandi S, Rastegarimehr B, Valipour A, Ranjbarzadeh A, Yari AR, et al. An investigation of particulate matter and relevant cardiovascular risks in Abadan and Khorramshahr in 2014–2016. Toxin Reviews. 2018:1-8.

30.          Nakhlband A, Eskandani M, Omidi Y, Saeedi N, Ghaffari S, Barar J, et al. Combating atherosclerosis with targeted nanomedicines: Recent advances and future prospective. BioImpacts. 2018;8(1):59-75.

31.          Nakhlband A, Eskandani M, Saeedi N, Ghafari S, Omidi Y, Barar J, et al. Marrubiin-loaded solid lipid nanoparticles’ impact on TNF-α treated umbilical vein endothelial cells: A study for cardioprotective effect. Colloids and Surfaces B: Biointerfaces. 2018;164:299-307.

32.          Neisi A, Albooghobeish M, Geravandi S, Adeli Behrooz HR, Mahboubi M, Omidi Khaniabad Y, et al. Investigation of health risk assessment sevoflurane on indoor air quality in the operation room in Ahvaz city, Iran. Toxin Reviews. 2018:1-9.

33.          Neisi A, Idani E, Vosoughi M, Hazrati S, Babaei AA, Takdastan A, et al. Answers to the comments on “Air pollution, biological marker and lung function in children”. Environmental Science and Pollution Research. 2018;25(27):27669-71.

34.          Nemati E, Azami A, Mokhtarzadeh A, Rahbar Saadat Y, Omidi Y, Ezzati Nazhad Dolatabadi J. Formulation and characterization of ethambutol loaded nanostructured lipid carrier. Latin American Journal of Pharmacy. 2017;36(2):247-52.

35.          Omidi Khaniabadi Y, Sicard P, Omidi Khaniabadi A, Mohammadinejad S, Keishams F, Takdastan A, et al. Air quality modeling for health risk assessment of ambient PM<inf>10</inf>, PM<inf>2.5</inf> and SO<inf>2</inf> in Iran. Human and Ecological Risk Assessment. 2018.

36.          Pakchin PS, Nakhjavani SA, Saber R, Ghanbari H, Omidi Y. Recent advances in simultaneous electrochemical multi-analyte sensing platforms. TrAC - Trends in Analytical Chemistry. 2017;92:32-41.

37.          Panahpour H, Farhoudi M, Omidi Y, Mahmoudi J. An in vivo assessment of blood-brain barrier disruption in a rat model of ischemic stroke. Journal of Visualized Experiments. 2018;2018(133).

38.          Parvizpour S, Razmara J, Omidi Y. Breast cancer vaccination comes to age: Impacts of bioinformatics. BioImpacts. 2018;8(3):223-35.

39.          Pourseif MM, Moghaddam G, Daghighkia H, Nematollahi A, Omidi Y. A novel B- and helper T-cell epitopes-based prophylactic vaccine against Echinococcus granulosus. BioImpacts. 2018;8(1):39-52.

40.          Pourseif MM, Moghaddam G, Naghili B, Saeedi N, Parvizpour S, Nematollahi A, et al. A novel in silico minigene vaccine based on CD4+ T-helper and B-cell epitopes of EG95 isolates for vaccination against cystic echinococcosis. Computational Biology and Chemistry. 2018;72:150-63.

41.          Pourseif MM, Moghaddam G, Saeedi N, Barzegari A, Dehghani J, Omidi Y. Current status and future prospective of vaccine development against Echinococcus granulosus. Biologicals : journal of the International Association of Biological Standardization. 2018;51:1-11.

42.          Rahmanian N, Eskandani M, Barar J, Omidi Y. Recent trends in targeted therapy of cancer using graphene oxide-modified multifunctional nanomedicines. Journal of Drug Targeting. 2017;25(3):202-15.

43.          Ranjbar-Navazi Z, Eskandani M, Johari-Ahar M, Nemati A, Akbari H, Davaran S, et al. Doxorubicin-conjugated D-glucosamine- and folate- bi-functionalised InP/ZnS quantum dots for cancer cells imaging and therapy. Journal of Drug Targeting. 2018;26(3):267-77.

44.          Rodriguez-Ruiz V, Salatti-Dorado JÁ, Barzegari A, Nicolas-Boluda A, Houaoui A, Caballo C, et al. Astaxanthin-loaded nanostructured lipid carriers for preservation of antioxidant activity. Molecules. 2018;23(10).

45.          Salmanzadeh R, Eskandani M, Mokhtarzadeh A, Vandghanooni S, Ilghami R, Maleki H, et al. Propyl gallate (PG) and tert-butylhydroquinone (TBHQ) may alter the potential anti-cancer behavior of probiotics. Food Bioscience. 2018;24:37-45.

46.          Samadi Pakchin P, Ghanbari H, Saber R, Omidi Y. Electrochemical immunosensor based on chitosan-gold nanoparticle/carbon nanotube as a platform and lactate oxidase as a label for detection of CA125 oncomarker. Biosensors and Bioelectronics. 2018;122:68-74.

47.          Shakoori Z, Ghanbari H, Omidi Y, Pashaiasl M, Akbarzadeh A, Jomeh Farsangi Z, et al. Fluorescent multi-responsive cross-linked P(N-isopropylacrylamide)-based nanocomposites for cisplatin delivery. Drug Development and Industrial Pharmacy. 2017;43(8):1283-91.

48.          Tohidkia MR, Sepehri M, Khajeh S, Barar J, Omidi Y. Improved Soluble ScFv ELISA Screening Approach for Antibody Discovery Using Phage Display Technology. SLAS Discovery. 2017;22(8):1026-34.

49.          Vandghanooni S, Eskandani M, Barar J, Omidi Y. AS1411 aptamer-decorated cisplatin-loaded poly(lactic-co-glycolic acid) nanoparticles for targeted therapy of miR-21-inhibited ovarian cancer cells. Nanomedicine. 2018;13(21).

50.          Vandghanooni S, Eskandani M, Barar J, Omidi Y. Bispecific therapeutic aptamers for targeted therapy of cancer: a review on cellular perspective. Journal of Molecular Medicine. 2018;96(9):885-902.

51.          Vandghanooni S, Eskandani M, Barar J, Omidi Y. Recent advances in aptamer-armed multimodal theranostic nanosystems for imaging and targeted therapy of cancer. European Journal of Pharmaceutical Sciences. 2018;117:301-12.

52.          Zamanlu M, Farhoudi M, Eskandani M, Mahmoudi J, Barar J, Rafi M, et al. Recent advances in targeted delivery of tissue plasminogen activator for enhanced thrombolysis in ischaemic stroke. Journal of Drug Targeting. 2018;26(2):95-109.

53.          Zeydouni G, Kianizadeh M, Omidi Khaniabadi Y, Nourmoradi H, Esmaeili S, Mohammadi MJ, et al. Eriochrme black-T removal from aqueous environment by surfactant modified clay: equilibrium, kinetic, isotherm, and thermodynamic studies. Toxin Reviews. 2018:1-11.

54.          Zeydouni G, Rodriguez Couto S, Nourmoradi H, Basiri H, Amoatey P, Esmaeili S, et al. H<inf>2</inf>SO<inf>4</inf>-modified Aloe vera leaf shells for the removal of P-chlorophenol and methylene blue from aqueous environment. Toxin Reviews. 2018:1-11.

55.          Zununi Vahed S, Barzegari A, Rahbar Saadat Y, Goreyshi A, Omidi Y. Leuconostoc mesenteroides-derived anticancer pharmaceuticals hinder inflammation and cell survival in colon cancer cells by modulating NF-κB/AKT/PTEN/MAPK pathways. Biomedicine and Pharmacotherapy. 2017;94:1094-100.

56.          Zununi Vahed S, Moghaddas Sani H, Rahbar Saadat Y, Barzegari A, Omidi Y. Type 1 diabetes: Through the lens of human genome and metagenome interplay. Biomedicine and Pharmacotherapy. 2018;104:332-42.

57.          Zununi Vahed S, Omidi Y, Ardalan M, Samadi N. Dysregulation of urinary miR-21 and miR-200b associated with interstitial fibrosis and tubular atrophy (IFTA) in renal transplant recipients. Clinical Biochemistry. 2017;50(1-2):32-9.

58.          Zununi Vahed S, Poursadegh Zonouzi A, Ghanbarian H, Ghojazadeh M, Samadi N, Omidi Y, et al. Differential expression of circulating miR-21, miR-142-3p and miR-155 in renal transplant recipients with impaired graft function. International Urology and Nephrology. 2017;49(9):1681-9.

59.          Zununi Vahed S, Poursadegh Zonouzi A, Mahmoodpoor F, Samadi N, Ardalan M, Omidi Y. Circulating miR-150, miR-192, miR-200b, and miR-423-3p as Non-invasive Biomarkers of Chronic Allograft Dysfunction. Archives of Medical Research. 2017;48(1):96-104.

60.          Hamishehkar H, Bahadori MB, Vandghanooni S, Eskandani M, Nakhlband A, Eskandani M. Preparation, characterization and anti-proliferative effects of sclareol-loaded solid lipid nanoparticles on A549 human lung epithelial cancer cells. Journal of Drug Delivery Science and Technology. 2018;45:272-80.

61.          Janani M, Jafari F, Samiei M, Lotfipour F, Nakhlband A, Ghasemi N, et al. Evaluation of antibacterial efficacy of photodynamic therapy vs. 2.5% NaOCl against E. faecalis-infected root canals using real-time PCR technique. Journal of Clinical and Experimental Dentistry. 2017;9(4):e539-e44.

62.          Nezhadhaghighi MG, Nakhlband A. Modeling and statistical analysis of non-Gaussian random fields with heavy-tailed distributions. Physical Review E. 2017;95(4).

63.          Dehghani J, Movafeghi A, Barzegari A, Barar J. Efficient and stable transformation of Dunaliella pseudosalina by 3 strains of Agrobacterium tumefaciens. BioImpacts. 2017;7(4):247-54.

64.          Fathi M, Barar J. Perspective highlights on biodegradable polymeric nanosystems for targeted therapy of solid tumors. BioImpacts. 2017;7(1):49-57.

65.          Jaymand M, Lotfi M, Barar J, Kimyai S. Synthesis and characterization of potential multifunctional methacrylate-based dental monomers. Research on Chemical Intermediates. 2017;43(10):5707-22.

66.          Johari-Ahar M, Barar J, Karami P, Asgari D, Davaran S, Rashidi MR. Nafion-coated cadmium pentacyanonitrosylferrate-modified glassy carbon electrode for detection of dopamine in biological samples. BioImpacts. 2018;8(4):263-70.

67.          Movahhedin N, Nazemiyeh H, Barar J, Esnaashari S, Movahhedin AH. Chemical constituent and biological activities of spatoglossum asperum J. Agardh from Oman sea. Letters in Drug Design and Discovery. 2018;15(3):263-9.

68.          Safary A, Khiavi MA, Mousavi R, Barar J, Rafi MA. Enzyme replacement therapies: What is the best option? BioImpacts. 2018;8(3):153-7.

69.          Salatin S, Barar J, Barzegar-Jalali M, Adibkia K, Jelvehgari M. Thermosensitive in situ nanocomposite of rivastigmine hydrogen tartrate as an intranasal delivery system: Development, characterization, ex vivo permeation and cellular studies. Colloids and Surfaces B: Biointerfaces. 2017;159:629-38.

70.          Salatin S, Barar J, Barzegar-Jalali M, Adibkia K, Kiafar F, Jelvehgari M. Development of a nanoprecipitation method for the entrapment of a very water soluble drug into Eudragit RL nanoparticles. Research in Pharmaceutical Sciences. 2017;12(1):1-14.

71.          Sattari M, Fathi M, Daei M, Erfan-Niya H, Barar J, Entezami AA. Thermoresponsive graphene oxide - Starch micro/nanohydrogel composite as biocompatible drug delivery system. BioImpacts. 2017;7(3):167-75.

72.          Geranmayeh MH, Nourazarian A, Avci ÇB, Rahbarghazi R, Farhoudi M. Stem Cells as a Promising Tool for the Restoration of Brain Neurovascular Unit and Angiogenic Orientation. Molecular Neurobiology. 2017;54(10):7689-705.

73.          Hasanpour M, Nourazarian A, Geranmayeh MH, Nikanfar M, Khaki-Khatibi F, Rahbarghazi R. The Dynamics of Neurosteroids and Sex-Related Hormones in the Pathogenesis of Alzheimer’s Disease. NeuroMolecular Medicine. 2018;20(2):215-24.

74.          Hosseini V, Dani C, Geranmayeh MH, Mohammadzadeh F, Nazari Soltan Ahmad S, Darabi M. Wnt lipidation: Roles in trafficking, modulation, and function. Journal of Cellular Physiology. 2018.

75.          Rezaie J, Ajezi S, Avci ÇB, Karimipour M, Geranmayeh MH, Nourazarian A, et al. Exosomes and their Application in Biomedical Field: Difficulties and Advantages. Molecular Neurobiology. 2018;55(4):3372-93.

76.          Sadigh-Eteghad S, Geranmayeh MH, Majdi A, Salehpour F, Mahmoudi J, Farhoudi
M. Intranasal cerebrolysin improves cognitive function and structural synaptic plasticity in photothrombotic mouse model of medial prefrontal cortex ischemia. Neuropeptides. 2018;71:61-9.