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 » Research Center for Pharmaceutical Nanotechnology, Research and Development Complex, Tabriz University of Medical Sciences, Daneshgah street, Tabriz, IRAN. Postal Code: 5165665811

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Technical approach

Research leader

Research assistants



Selected publications


Natural products have been the main members of cancer chemotherapy for the at least last decades. This laboratory is concerned about all experimental works associated to the broadcast and elucidation of novel native compounds extracted from nature and spotlights on the medicinal plants with antioxidant, antimicrobial and anti-cancer properties. Another goal of the Nanobiomaterial lab is assessment of pharmaceutical properties of pure extracted compounds through different cellular and molecular pathways. The laboratory is also fill the gaps between traditional medicine and high-tech sciences through formulation of natural pure products in different pharmaceutical tagged vehicles such as Solid Lipid Nanoparticles, Magnetic Nanoparticle, Nanostructured Lipid Carrier and so on for targeted drug delivery. In this lab, the biotechnological works, which improve the quality and quantity of biomaterials, is also set up.


Technical approach

Extraction of natural products

  • Natural product extraction using dry and wet methods

  • Essential oil extraction using Clevenger apparatus

  • Evaporator rotary

Purification of natural products

  • Analytical and preparative- Thin Layer Chromatography (TLC)

  • Vacuum Liquid Chromatography (VLC)

  • Column Chromatography (CC)

  • Semi-Preparative High Pressure Liquid Chromatography (Semi-Prep HPLC) 

Identification of natural products

  • UV-Visible Spectrometry

  • H and C NMR (in collaboration with other research centers)

Improving the quality and quantity of biomaterials
  • Shaker Incubator

  • Class I and II box hoods

Lipidic Nanoparticle synthesizing

  • Ultra-homogenizer

  • Dialysis 

Assessment of natural products properties

  • Anti-oxidant activity assay (DPPH)

  • Anti-microbial activity assays (In collaboration with Molecular Medicine & Therapy Lab)

  • Anti-angiogenesis activity assay (Chorioallantoic Membrane Angiogenesis Assay

Research Leader

Professor. Hossein Nazemiyeh, (PharmD; PhD)


Research Assistants

Mir-Babak Bahadori


Dr. Morteza Eskandani (M.Sc, Ph.D)



PhD students

Babak Bahadori studied applied chemistry at the university of Tabriz and obtained his BSc. degree in 2009. Babak received a MSc. degree in phytochemistry with his thesis entitled "Phytochemical investigation of Salvia urmiensis" at Shahid Beheshti university in September 2011 under the supervision of Prof. Peyman Salehi and Dr. Mahdi Moridi Farimani. He joined the research group of Prof. Valizadeh at the university of Azerbaijan as a PhD student in 2011.  He joined the scientific group of Prof. Nazemiyeh in the RCPN as a visiting researcher in August 2014. His PhD project focused on “natural product drug-discovery” using a bioassay-guided isolation approach, from Iranian Medicinal plants.

Marzieh Babashpour-Asl graduated from the University of Tabriz with a BSc. degree in Agriculture in September 1999. In December 2001 she received MSc. degree from Tehran University in Floriculture. Babashpour joined to Islamic Azad University, Maragheh branch as a faculty member in March 2006. She was accepted as a PhD student of Medicinal Plants in Guilan University in September 2012. Her thesis entitled "Galanthamine production in Galanthus transcaucasicus Fomin in in vitro conditions " is under the supervision of Prof. Nazemiyeh in the RCPN and Prof. Zakizadeh from Gulian University.

Selected Publication

Last two years publications (2014-2015)

[1].Akbari, F., Eskandani, M., Khosroushahi, A.Y. (2014). The potential of transgenic green microalgae; a robust photobioreactor to produce recombinant therapeutic proteins, World J. Microbiol. Biotechnol. 30, 2783-96.

[2].Dolatabadi, J.E.N., Hamishehkar, H., Eskandani, M., Valizadeh, H. (2014). Formulation, characterization and cytotoxicity studies of alendronate sodium-loaded solid lipid nanoparticles, Colloids Surf. B Biointerfaces. 117, 21-8.

[3].Eskandani, M., Abdolalizadeh, J., Hamishehkar, H., Nazemiyeh, H., Barar, J. (2015). Galbanic acid inhibits HIF-1α expression via EGFR/HIF-1α pathway in cancer cells, Fitoterapia. 101, 1-11.

[4].Eskandani, M., Barar, J., Ezzati Nazhad Dolatabadi, J., Hamishehkar, H., Nazemiyeh, H. (2015). Formulation, characterization and geno/cytotoxicity studies of galbanic acid-loaded solid lipid nanoparticles, Pharmaceutical Biology. 10.3109/13880209.2014.991836.

[5].Eskandani, M., Dadizadeh, E., Hamishehkar, H., Nazemiyeh, H., Barar, J. (2014). Geno/cytotoxicty and apoptotic properties of phenolic compounds from the seeds of Dorema glabrum Fisch. C.A, BioImpacts. 4, 191-8.

[6].Eskandani, M., Hamishehkar, H., Ezzati Nazhad Dolatabadi, J. (2014). Cytotoxicity and DNA damage properties of tert-butylhydroquinone (TBHQ) food additive, Food Chem. 153, 315-20.

[7].Eskandani, M., Nazemiyeh, H. (2014). Self-reporter shikonin-Act-loaded solid lipid nanoparticle: Formulation, physicochemical characterization and geno/cytotoxicity evaluation, Eur. J. Pharm. Sci. 59, 49-57.

[8].Hamishehkar, H., Khani, S., Kashanian, S., Ezzati Nazhad Dolatabadi, J., Eskandani, M. (2014). Geno- and cytotoxicity of propyl gallate food additive, Drug Chem. Toxicol. 37, 241-6.

[9].Hasanzadeh, M., Shadjou, N., Eskandani, M., Soleymani, J., Jafari, F., de la Guardia, M. (2014). Dendrimer-encapsulated and cored metal nanoparticles for electrochemical nanobiosensing, TrAC Trends Anal. Chem. 53, 137-49.

[10].Kafil, V., Eskandani, M., Omidi, Y., Nazemiyeh, H., Barar, J. (2015). Abietane diterpenoid of Salvia sahendica Boiss and Buhse potently inhibits MCF-7 breast carcinoma cells by suppression of the PI3K/AKT pathway, RSC Adv. 5, 18041-50.

[11].Salehi, R., Hamishehkar, H., Eskandani, M., Mahkam, M., Davaran, S. (2014). Development of dual responsive nanocomposite for simultaneous delivery of anticancer drugs, J. Drug Targeting. 22, 327-42.

[12].Salehi, R., Irani, M., Eskandani, M., Nowruzi, K., Davaran, S., Haririan, I. (2014). Interaction, controlled release, and antitumor activity of doxorubicin hydrochloride from pH-sensitive P(NIPAAm-MAA-VP) nanofibrous scaffolds prepared by green electrospinning, Int. J. Polym. Mater. Polym. Biomater. 63, 609-19.

[13].Hamedeyazdan, S., Sharifi, S., Nazemiyeh, H., Fathiazad, F. (2014). Evaluating antiproliferative and antioxidant activity of Marrubium crassidens, Adv. Pharm. Bull. 4, 459-64.

[14].Keyhanmanesh, R., Nazemiyeh, H., Mazouchian, H., Bagheri Asl, M.M., Karimi Shoar, M., Alipour, M.R., et al. (2014). Nigella sativa pretreatment in guinea pigs exposed to cigarette smoke modulates in vitro tracheal responsiveness, Iran. Red Crescent Med.J. 16,

[15].Kia, P.Y., Safajou, F., Shahnazi, M., Nazemiyeh, H. (2014). The effect of lemon inhalation aromatherapy on nausea and vomiting of pregnancy: A double-blinded, randomized, controlled clinical trial, Iran. Red Crescent Med.J. 16,

[16].Madani Mousavi, S.N., Delazar, A., Nazemiyeh, H., Khodaie, L. (2015). Biological activity and phytochemical study of Scutellaria platystegia, Iran. J. Pharm. Res. 14, 215-23.

[17].Mohammad-Alizadeh-Charandabi, S., Mirghafourvand, M., Aghamiri, V., Nazemiyeh, H., Soltanpoor, S. (2014). Efficacy of hop (Humuluslupulus L.) on early menopausal symptoms in perimenopausal women: A randomized double blind placebo-controlled trial, Sci. J. Kurdistan Univ. Med. Sci. 19, 12-22.

[18].Movahhedin, N., Barar, J., Azad, F.F., Barzegari, A., Nazemiyeh, H. (2014). Phytochemistry and biologic activities of caulerpa peltata native to Oman sea, Iran. J. Pharm. Res. 13, 515-21.

[19].Nazemiyeh, M., Rashidi, F., Gharemohammadlou, R. (2014). A rare presentation of pulmonary sarcoidosis with massive hemoptysis, Arch. Iran. Med. 17, 84-5.

[20].Piryaei, M., Abolghasemi, M.M., Nazemiyeh, H. (2014). Fast determination of Ziziphora tenuior L. essential oil by inorganic–organic hybrid material based on ZnO nanoparticles anchored to a composite made from polythiophene and hexagonally ordered silica, Nat. Prod. Res.

[21].piryaei, M., Abolghasemi, M.M., Nazemiyeh, H. (2015). Rapid analysis of Achillea tenuifolia Lam essential oils by polythiophene/hexagonally ordered silica nanocomposite coating as a solid-phase microextraction fibre, Nat. Prod. Res.

[22].Torbati, M., Nazemiyeh, H., Lotfipour, F., Nemati, M., Asnaashari, S., Fathiazad, F. (2014). Chemical composition and in vitro antioxidant and antibacterial activity of Heracleum transcaucasicum and Heracleum anisactis roots essential oil, BioImpacts. 4, 69-74.

[23].Zare, K., Movafeghi, A., Mohammadi, S.A., Asnaashari, S., Nazemiyeh, H. (2014). New phenolics from Linum mucronatum subsp. Orientale, BioImpacts. 4, 117-21.