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Research Center for Pharmaceutical Nanotechnology, Research and Development Complex, Tabriz University of Medical Sciences, Daneshgah street, Tabriz, IRAN. Postal Code: 5165665811

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T +98 (41) 33367914
F +98 (41) 33367929  
E nano@tbzmed.ac.ir



 
 Nanobiomaterial


Technical approach

Research leader

Research assistants

Researcher

Students

Selected publications


Nanobiomaterial

Natural products have been the main members of cancer chemotherapy for the at least last decades. This laboratory is concerned about all experimental works associated to the broadcast and elucidation of novel native compounds extracted from nature and spotlights on the medicinal plants with antioxidant, antimicrobial and anti-cancer properties. Another goal of the Nanobiomaterial lab is assessment of pharmaceutical properties of pure extracted compounds through different cellular and molecular pathways. The laboratory is also fill the gaps between traditional medicine and high-tech sciences through formulation of natural pure products in different pharmaceutical tagged vehicles such as Solid Lipid Nanoparticles, Magnetic Nanoparticle, Nanostructured Lipid Carrier and so on for targeted drug delivery. In this lab, the biotechnological works, which improve the quality and quantity of biomaterials, is also set up.


Technical approach

Extraction of natural products

Natural product extraction using dry and wet methods

Essential oil extraction using Clevenger apparatus

 Evaporator rotary

Purification of natural products

Analytical and preparative- Thin Layer Chromatography (TLC)

Vacuum Liquid Chromatography (VLC)

Column Chromatography (CC)

Semi-Preparative High Pressure Liquid Chromatography (Semi-Prep HPLC) 

Identification of natural products

UV-Visible Spectrometry

H and C NMR (In collaboration with other research centers)

Improving the quality and quantity of biomaterials

Shaker Incubator

Class I and II box hoods

Lipidic Nanoparticle synthesizing

Ultra-homogenizer

Dialysis 

Assessment of natural products properties

Anti-oxidant activity assay (DPPH)

Anti-microbial activity assays (In collaboration with Molecular Medicine & Therapy Lab)

Anti-angiogenesis activity assay (Chorioallantoic Membrane Angiogenesis Assay



Research Leader

Professor. Hossein Nazemiyeh, (PharmD; PhD)


Researchers

Dr. Morteza Eskandani (M.Sc, Ph.D), Click here to see CV


Research Assistant

Mir-Babak Bahadori, Click here to see CV

 

Students

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Selected Publication

Hatamzadeh, M., Jaymand, M., Massoumia, B., Graft copolymerization of thiophene onto polystyrene synthesized via nitroxide-mediated polymerization and its polymer−clay nanocomposite. Polymer International, 2013, [In Press]

Hatamzadeh, M., Johari-Ahar, M., Jaymand, M., In situ chemical oxidative graft polymerization of aniline from Fe3O4 nanoparticles, International journal of Nanoscience and nanotechnology, 2013, [In Press]

Heidari Majd, M., Asgari, D. , Barar, J., Valizadeh, H., Kafil, V., Coukos, G., Omidi, Y., Specific targeting of cancer cells by multifunctional mitoxantrone- conjugated magnetic nanoparticles, Journal of Drug Targeting, 2013, 21; 328-340.

Majd, M.H., Barar, J., Asgari, D., Valizadeh, H., Rashidi, M.R., Kafil, V., Shahbazi, J., Omidi, Y., Targeted fluoromagnetic nanoparticles for imaging of breast cancer MCF-7 cells, Advanced Pharmaceutical Bulletin, 2013, 3; 189-195