Natural products have been the main members of cancer chemotherapy for the at least last decades. This laboratory is concerned about all experimental works associated to the broadcast and elucidation of novel native compounds extracted from nature and spotlights on the medicinal plants with antioxidant, antimicrobial and anti-cancer properties. Another goal of the Nanobiomaterial lab is assessment of pharmaceutical properties of pure extracted compounds through different cellular and molecular pathways. The laboratory is also fill the gaps between traditional medicine and high-tech sciences through formulation of natural pure products in different pharmaceutical tagged vehicles such as Solid Lipid Nanoparticles, Magnetic Nanoparticle, Nanostructured Lipid Carrier and so on for targeted drug delivery. In this lab, the biotechnological works, which improve the quality and quantity of biomaterials, is also set up.
Extraction of natural products
Natural product extraction using dry and wet methods
Essential oil extraction using Clevenger apparatus
Purification of natural products
Analytical and preparative- Thin Layer Chromatography (TLC)
Vacuum Liquid Chromatography (VLC)
Column Chromatography (CC)
Semi-Preparative High Pressure Liquid Chromatography (Semi-Prep HPLC)
Identification of natural products
H and C NMR (in collaboration with other research centers)
Improving the quality and quantity of biomaterials
Class I and II box hoods
Lipidic Nanoparticle synthesizing
Assessment of natural products properties
Anti-oxidant activity assay (DPPH)
Anti-microbial activity assays (In collaboration with Molecular Medicine & Therapy Lab)
Anti-angiogenesis activity assay (Chorioallantoic Membrane Angiogenesis Assay
Professor. Hossein Nazemiyeh, (PharmD; PhD)
Researchers Dr. Morteza Eskandani (M.Sc, Ph.D), Click here to see CV
Mir-Babak Bahadori, Click here to see CV
Babak Bahadori studied apply chemistry at the university of Tabriz and obtained his BSc. degree in 2009. Babak received a MSc. degree in phytochemistry with his thesis entitled "Phytochemical investigation of Salvia urmiensis" at Shahid Beheshti university in September 2011 under the supervision of Prof. Peyman Salehi and Dr. Mahdi Moridi Farimani. He joined the research group of Prof. Valizadeh at the university of Azerbaijan as a PhD student in 2011. He joined the scientific group of Prof. Nazemiyeh in the RCPN as a visiting researcher in August 2014. His PhD project focused on “natural product drug-discovery” using a bioassay-guided isolation approach, from Iranian Medicinal plants.
Marzieh Babashpour-Asl graduated from the University of Tabriz with a BSc. degree in Agriculture in September 1999. In December 2001 she received MSc. degree from Tehran University in Floriculture. Babashpour joined to Islamic Azad University, Maragheh branch as a faculty member in March 2006. She was accepted as a PhD student of Medicinal Plants in Guilan University in September 2012. Her thesis entitled "Galanthamine production in Galanthus transcaucasicus Fomin in in vitro conditions " is under the supervision of Prof. Nazemiyeh in the RCPN and Prof. Zakizadeh from Gulian University.
Hatamzadeh, M., Jaymand, M., Massoumia, B., Graft copolymerization of thiophene onto polystyrene synthesized via nitroxide-mediated polymerization and its polymer−clay nanocomposite. Polymer International, 2013, [In Press]
Hatamzadeh, M., Johari-Ahar, M., Jaymand, M., In situ chemical oxidative graft polymerization of aniline from Fe3O4 nanoparticles, International journal of Nanoscience and nanotechnology, 2013, [In Press]
Heidari Majd, M., Asgari, D. , Barar, J., Valizadeh, H., Kafil, V., Coukos, G., Omidi, Y., Specific targeting of cancer cells by multifunctional mitoxantrone- conjugated magnetic nanoparticles, Journal of Drug Targeting, 2013, 21; 328-340.
Majd, M.H., Barar, J., Asgari, D., Valizadeh, H., Rashidi, M.R., Kafil, V., Shahbazi, J., Omidi, Y., Targeted fluoromagnetic nanoparticles for imaging of breast cancer MCF-7 cells, Advanced Pharmaceutical Bulletin, 2013, 3; 189-195