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 » Research Center for Pharmaceutical Nanotechnology, Research and Development Complex, Tabriz University of Medical Sciences, Daneshgah street, Tabriz, IRAN. Postal Code: 5165665811

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  Natural/synthetic drug screening

Technical approach

Research leader

Research assistants

Post-doc researchers


Selected publications


Natural/synthetic drug screening


Natural products have been the main members of cancer chemotherapy for the at least last decades. This laboratory is concerned about all experimental works associated to the broadcast and elucidation of novel native compounds extracted from nature and spotlights on the medicinal plants with antioxidant, antimicrobial and anti-cancer properties. Another goal of the Nanobiomaterial lab is assessment of pharmaceutical properties of pure extracted compounds through different cellular and molecular pathways. The laboratory is also fill the gaps between traditional medicine and high-tech sciences through formulation of natural pure products in different pharmaceutical tagged vehicles such as Solid Lipid Nanoparticles, Magnetic Nanoparticle, Nanostructured Lipid Carrier and so on for targeted drug delivery. In this lab, the biotechnological works, which improve the quality and quantity of biomaterials, is also set up.




Technical approach

Extraction of natural products

  • Natural product extraction using dry and wet methods

  • Essential oil extraction using Clevenger apparatus

  • Evaporator rotary


Purification of natural products

  • Analytical and preparative- Thin Layer Chromatography (TLC)

  • Vacuum Liquid Chromatography (VLC)

  • Column Chromatography (CC)

  • Semi-Preparative High Pressure Liquid Chromatography (Semi-Prep HPLC) 


Identification of natural products

  • UV-Visible Spectrometry

  • H and C NMR (in collaboration with other research centers)


Improving the quality and quantity of biomaterials
  • Shaker Incubator
  • Class I and II box hoods
Lipidic Nanoparticle synthesizing
  • Ultra-homogenizer
  • Dialysis 
Assessment of natural products properties
  • Anti-oxidant activity assay (DPPH)
  • Anti-microbial activity assays (In collaboration with Molecular Medicine & Therapy Lab)
  • Anti-angiogenesis activity assay (Chorioallantoic Membrane Angiogenesis Assay

Research Leader

Professor. Hossein Nazemiyeh, (PharmD; PhD)
Dr. Morteza Eskandani (M.Sc, Ph.D)
Dr. Abolfazl Barzegari (M.Sc,PhD)
Dr.Jaber  dehghani,(M.Sc,PhD)


Research Assistants

Faezeh Bakhshi

Post-doc researchers
 Will be updated ASAP.


PhD students
Will be updated ASAP.

Selected Publication based on scopus
Last two years publications (2017-2018)

1.            Abbasian M, Roudi MM, Mahmoodzadeh F, Eskandani M, Jaymand M. Chitosan-grafted-poly(methacrylic acid)/graphene oxide nanocomposite as a pH-responsive de novo cancer chemotherapy nanosystem. International Journal of Biological Macromolecules 2018; 118: 1871-9. doi:10.1016/j.ijbiomac.2018.07.036.


2.            Ahani N, Sangtarash MH, Houshmand M, Eskandani MA. Genipin induces cell death via intrinsic apoptosis pathways in human glioblastoma cells. Journal of Cellular Biochemistry 2018. doi:10.1002/jcb.27512.


3.            Ahmadi R, Eskandani MA, Saadati D. Evaluation of antimicrobial effect of Iranian sumac on Bacillus cereus in a commercial barley soup. Slovenian Veterinary Research 2017; 54: 65-9.


4.            Alizadeh N, Eskandani M, Tondro K, Rashidi MR, Nazemiyeh H. Inhibitory effects of flavonolignans from silybum marianum (L.) gaertn (milk thistle) on function of aldehyde oxidase and xanthine oxidase in rats. Letters in Drug Design and Discovery 2018; 15: 256-62. doi:10.2174/1570180814666170420110005.


5.            Anvari D, Saadati D, Nabavi R, Alipour Eskandani M. Epidemiology and molecular prevalence of Toxoplasma gondii in cattle Slaughtered in Zahedan and Zabol Districts, South East of Iran. Iranian Journal of Parasitology 2018; 13: 114-9.


6.            Asgharzadeh MR, Barar J, Pourseif MM, Eskandani M, Niya MJ, Mashayekhi MR, et al. Molecular machineries of pH dysregulation in tumor microenvironment: Potential targets for cancer therapy. BioImpacts 2017; 7: 115-33. doi:10.15171/bi.2017.15.


7.            Bahadori MB, Eskandani M, De Mieri M, Hamburger M, Nazemiyeh H. Anti-proliferative activity-guided isolation of clerodermic acid from Salvia nemorosa L.: Geno/cytotoxicity and hypoxia-mediated mechanism of action. Food and Chemical Toxicology 2018; 120: 155-63. doi:10.1016/j.fct.2018.06.060.


8.            Eskandani M, Vandghanooni S, Barar J, Nazemiyeh H, Omidi Y. Cell physiology regulation by hypoxia inducible factor-1: Targeting oxygen-related nanomachineries of hypoxic cells. International Journal of Biological Macromolecules 2017; 99: 46-62. doi:10.1016/j.ijbiomac.2016.10.113.


9.            Hamishehkar H, Bahadori MB, Vandghanooni S, Eskandani M, Nakhlband A, Eskandani M. Preparation, characterization and anti-proliferative effects of sclareol-loaded solid lipid nanoparticles on A549 human lung epithelial cancer cells. Journal of Drug Delivery Science and Technology 2018; 45: 272-80. doi:10.1016/j.jddst.2018.02.017.


10.          Jafarizad A, Taghizadehgh-Alehjougi A, Eskandani M, Hatamzadeh M, Abbasian M, Mohammad-Rezaei R, et al. PEGylated graphene oxide/Fe<inf>3</inf>O<inf>4</inf>site: Synthesis, characterization, and evaluation of its performance as de novo drug delivery nanosystem. Bio-Medical Materials and Engineering 2018; 29: 177-90. doi:10.3233/BME-171721.


11.          Nakhlband A, Eskandani M, Omidi Y, Saeedi N, Ghaffari S, Barar J, et al. Combating atherosclerosis with targeted nanomedicines: Recent advances and future prospective. BioImpacts 2018; 8: 59-75. doi:10.15171/bi.2018.08.


12.          Nakhlband A, Eskandani M, Saeedi N, Ghafari S, Omidi Y, Barar J, et al. Marrubiin-loaded solid lipid nanoparticles’ impact on TNF-α treated umbilical vein endothelial cells: A study for cardioprotective effect. Colloids and Surfaces B: Biointerfaces 2018; 164: 299-307. doi:10.1016/j.colsurfb.2018.01.046.


13.          Nazemi K, Salari S, Eskandani MA. Assessment of the escherichia coli pollution in drinking water and water sources in sistan, iran. Journal of Water Reuse and Desalination 2018; 8: 386-92. doi:10.2166/wrd.2017.146.


14.          Rahmanian N, Eskandani M, Barar J, Omidi Y. Recent trends in targeted therapy of cancer using graphene oxide-modified multifunctional nanomedicines. Journal of Drug Targeting 2017; 25: 202-15. doi:10.1080/1061186X.2016.1238475.


15.          Ranjbar-Navazi Z, Eskandani M, Johari-Ahar M, Nemati A, Akbari H, Davaran S, et al. Doxorubicin-conjugated D-glucosamine- and folate- bi-functionalised InP/ZnS quantum dots for cancer cells imaging and therapy. Journal of Drug Targeting 2018; 26: 267-77. doi:10.1080/1061186X.2017.1365876.


16.          Salmanzadeh R, Eskandani M, Mokhtarzadeh A, Vandghanooni S, Ilghami R, Maleki H, et al. Propyl gallate (PG) and tert-butylhydroquinone (TBHQ) may alter the potential anti-cancer behavior of probiotics. Food Bioscience 2018; 24: 37-45. doi:10.1016/j.fbio.2018.05.005.


17.          Soleymani J, Hasanzadeh M, Eskandani M, Khoubnasabjafari M, Shadjou N, Jouyban A. Electrochemical sensing of doxorubicin in unprocessed whole blood, cell lysate, and human plasma samples using thin film of poly-arginine modified glassy carbon electrode. Materials Science and Engineering C 2017; 77: 790-802. doi:10.1016/j.msec.2017.03.257.


18.          Vandghanooni S, Eskandani M, Barar J, Omidi Y. Bispecific therapeutic aptamers for targeted therapy of cancer: a review on cellular perspective. Journal of Molecular Medicine 2018; 96: 885-902. doi:10.1007/s00109-018-1669-y.


19.          Vandghanooni S, Eskandani M, Barar J, Omidi Y. Recent advances in aptamer-armed multimodal theranostic nanosystems for imaging and targeted therapy of cancer. European Journal of Pharmaceutical Sciences 2018; 117: 301-12. doi:10.1016/j.ejps.2018.02.027.


20.          Zamanlu M, Eskandani M, Mohammadian R, Entekhabi N, Rafi M, Farhoudi M. Spectrophotometric analysis of thrombolytic activity: SATA assay. BioImpacts 2018; 8: 31-8. doi:10.15171/bi.2018.05.


21.          Zamanlu M, Farhoudi M, Eskandani M, Mahmoudi J, Barar J, Rafi M, et al. Recent advances in targeted delivery of tissue plasminogen activator for enhanced thrombolysis in ischaemic stroke. Journal of Drug Targeting 2018; 26: 95-109. doi:10.1080/1061186X.2017.1365874.


22.          Afshar FH, Delazar A, Nazemiyeh H, Nahar L, Moghaddam SB, Mbaebie BO, et al. Melilotoside derivatives from Artemisia splendens (Asteraceae). Records of Natural Products 2017; 11: 43-50.


23.          Delazar A, Nazemiyeh H, Afshar F, Barghi N, Esnaashari S, Asgharian P. Chemical compositions and biological activities of Scutellaria pinnatifida A. Hamilt aerial parts. Research in Pharmaceutical Sciences 2017; 12: 187-95. doi:10.4103/1735-5362.207199.


24.          Khodadadi A, Nemati M, Tamizi E, Nazemiyeh H. Facile and accelerated method for detection of adulteration in commercially available lime juice products in Iranian market. Pharmaceutical Sciences 2018; 24: 148-56. doi:10.15171/PS.2018.22.


25.          Kirimer N, Suleymanov TA, Kurkcuoglu M, Nazemiyeh H, Shukurova AS, Jouyban A. Essential oil constituents of phlomis pungens willd. From Azerbaijan. Journal of Essential Oil-Bearing Plants 2017; 20: 1492-501. doi:10.1080/0972060X.2017.1407261.


26.          Mahmoodpoor A, Medghalchi M, Nazemiyeh H, Asgharian P, Shadvar K, Hamishehkar H. Effect of Cucurbita Maxima on control of blood glucose in diabetic critically Ill patients. Advanced Pharmaceutical Bulletin 2018; 8: 347-51. doi:10.15171/apb.2018.040.


27.          Moini Jazani A, Hamdi K, Tansaz M, Nazemiyeh H, Sadeghi Bazargani H, Fazljou SMB, et al. Herbal Medicine for Oligomenorrhea and Amenorrhea: A Systematic Review of Ancient and Conventional Medicine. BioMed research international 2018; 2018: 3052768. doi:10.1155/2018/3052768.


28.          Movahhedin N, Nazemiyeh H, Barar J, Esnaashari S, Movahhedin AH. Chemical constituent and biological activities of spatoglossum asperum J. Agardh from Oman sea. Letters in Drug Design and Discovery 2018; 15: 263-9. doi:10.2174/1570180814666170407103936.


29.          Nasimi Doost Azgomi R, Nazemiyeh H, Sadeghi Bazargani H, Fazljou SMB, Nejatbakhsh F, Moini Jazani A, et al. Comparative evaluation of the effects of Withania somnifera with pentoxifylline on the sperm parameters in idiopathic male infertility: A triple-blind randomised clinical trial. Andrologia 2018; 50. doi:10.1111/and.13041.


30.          Yaripour S, Delnavazi MR, Asgharian P, Valiyari S, Tavakoli S, Nazemiyeh H. A survey on phytochemical composition and biological activity of Zygophyllum Fabago from Iran. Advanced Pharmaceutical Bulletin 2017; 7: 109-14. doi:10.15171/apb.2017.014.