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 » Research Center for Pharmaceutical Nanotechnology, Research and Development Complex, Tabriz University of Medical Sciences, Daneshgah street, Tabriz, IRAN. Postal Code: 5165665811

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  Nanobiomaterial engineering

Technical approach

Research leader

Research assistants

Post-doc researchers


Selected publications

Nanobiomaterials engineering 

Advances in nano-medicine can be made by engineering multifunctional biodegradable nanoparticles such as, polymers, dendrimers, liposomes and inorganic nanoparticles (especially Fe3O4 and SiO2) that are capable of targeted delivery of drugs.

Technical approach

Synthesis and engineering multifunctional biodegradable nanoparticles for targeted drug delivery

Synthesis and modification of inorganic nanoparticles for targeted drug delivery and medical applications


Research leaders

Dr. Ayuob Aghanejad, (M.Sc, Ph.D)
Dr. Morteza Eskandani, (M.Sc, Ph.D)
Prof. Yadollah Omidi, (PharmD, Ph.D)


Research Assistants

Will be updated ASAP.


Post-doc researchers

Dr. Marziyeh Fathi (M.Sc, PhD)

Dr. Zahra Ranjbar (M.Sc, PhD)



PhD Students

Parvin Samadi obtained her diploma of experimental of sciences (2005) from Tabriz Farzaneghan high school, a member of NODET (National Organization for Development of Exceptional Talent). In 2004, she won a bronze medal in the 7th National Biology Olympiad in Tehran; she is a member of National Elites Foundation. She obtained her B.Sc. degree in Applied Chemistry (2009), from Tabriz University & M.Sc. degree (2011) in Applied Chemistry from Chemistry and Chemical Engineering Research Center of Iran (CCERC), her thesis was about synthesis of inorganic nanotubes under the supervision of Dr. Zolfaghari and Dr. Mortaheb, while she was top student selected as the example student of the center. She started her PhD (2013) in medical nanotechnology in Tehran University of medical science, under the supervision of Dr.Ghanbari. She aimed her PhD project at electrochemical nanobiosensor for cancer, under supervision of Prof. Y. Omidi, and she has joined our center as a student researcher.
Sattar Akbari Nakhjavani was born in Tabriz, Iran, in 1984. He received the Doctorate degree in veterinary medicine from Islamic Azad University, Tabriz branch, Iran, in 2008. In 2013, he joined the department of molecular medicine, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, as a PhD student. He is currently performing his PhD thesis in Research Center of Pharmaceutical Nanotechnology (RCPN) under the supervision of Professor Yadollah Omidi and Professor Mohammad Hossein Ghahremani on application of biosensors in cancer diagnosis. He is a member of Iranian Society for Immunology and Allergy since 2012. His research focused on early detection of cancer and neurodegenerative disease, biosensors, nanoparticulated drug delivery and targeting, and finally probiotics and their roles in health. Contact info: or
Farzaneh Fathi is a first year PhD by research student in the field of biosensors that supervised by Dr Mohammad Reza Rashidi in Research Center for Pharmaceutical Nanotechnology (RCPN) in Tabriz University of Medical Sciences.  Her research is focused on surface plasnmon resonance (SPR) methods and developed biosensors based on it in her PhD thesis. She was born in Tabriz, Iran. She received a BS in Pure Chemistry from Tabriz University in 2007 and a MS in organic chemistry from Tabriz University in 2010. She has been working since 2007 in Research Laboratory of Dendrimers and Nanobiopolymers on his project in ' Synthesize of Hydrophobically Modified Starches'. She has published more than 4 scientific papers and a book in relation to nanoparticles based on polysaccharides.
karim Osouli-Bostanabad has obtained hisB.Sc. degree from Foulad Institute of Technology and his M.Sc. degree from University of Tabriz as rank 3rd top student in the field of materials science and engineering. He is working as a lecture and teach some courses such as Fundamentals of Materials Science and Engineering, Technical Computing, Industrial Design (materials and manufacturing guide) and etc. in Islamic Azad University and Tabriz Islamic Art University. Furthermore, he has more than 4 years of experience as Chairman of the Board of Azerbaijan Composite Technologists Knowledge based Company in Materials Engineering field, covering a wide range from Magnetic Materials, Nanotechnology and Surface Engineering to Materials Processing and Industrial Machinery Design. Currently, He is a PhD candidate of pharmaceutical nanotechnology in Research Center for Pharmaceutical Nanotechnology at Tabriz University of Medical Sciences working on “Preparation, optimization and in vitro evaluation of simultaneous anticancer drugs delivery via electrosprayed nanosystems” under supervision of Prof. Khosro Adibkia and Prof. Yadollah Omidi. Among his accomplishments, at 2017 he was selected as a Top Researcher and Entrepreneurship in the First Festival of Technology, Entrepreneurship and Student Research of Tabriz University of Medical Sciences. Also, he selected as a Top Engineer in the First Festival of Selection of Best Engineers of East Azerbaijan Province. He has published 1 patent and more than 15 articles in the scientific international and national journals and conferences.


Selected Publication based on scopus

Last two years publications (2017-2018)

1.         Abdollahi-Aghdam A, Majidi MR, Omidi Y. Microfluidic paper-based analytical devices (µPADs) for fast and ultrasensitive sensing of biomarkers and monitoring of diseases. BioImpacts. 2018;8(4):237-40.

2.         Aghanejad A, Babamiri H, Adibkia K, Barar J, Omidi Y. Mucin-1 aptamer-armed superparamagnetic iron oxide nanoparticles for targeted delivery of doxorubicin to breast cancer cells. BioImpacts. 2018;8(2):117-27.

3.         Akbari Nakhjavani S, Khalilzadeh B, Samadi Pakchin P, Saber R, Ghahremani MH, Omidi Y. A highly sensitive and reliable detection of CA15-3 in patient plasma with electrochemical biosensor labeled with magnetic beads. Biosensors and Bioelectronics. 2018;122:8-15.

4.         Arteshi Y, Aghanejad A, Davaran S, Omidi Y. Biocompatible and electroconductive polyaniline-based biomaterials for electrical stimulation. European Polymer Journal. 2018;108:150-70.

5.         Asghari S, Movafeghi A, Lisar SYS, Barar J, Omidi Y. Effects of phenanthrene on growth parameters and antioxidant systems in the green microalga chlorella vulgaris. Biointerface Research in Applied Chemistry. 2018;8(4):3405-11.

6.         Asgharzadeh MR, Barar J, Pourseif MM, Eskandani M, Niya MJ, Mashayekhi MR, et al. Molecular machineries of pH dysregulation in tumor microenvironment: Potential targets for cancer therapy. BioImpacts. 2017;7(2):115-33.

7.         Asoudeh-Fard A, Barzegari A, Dehnad A, Bastani S, Golchin A, Omidi Y. Lactobacillus plantarum induces apoptosis in oral cancer KB cells through upregulation of PTEN and downregulation of MAPK signaling pathways. BioImpacts. 2017;7(3):193-8.

8.         Bakhtiary Z, Barar J, Aghanejad A, Saei AA, Nemati E, Ezzati Nazhad Dolatabadi J, et al. Microparticles containing erlotinib-loaded solid lipid nanoparticles for treatment of non-small cell lung cancer. Drug Development and Industrial Pharmacy. 2017;43(8):1244-53.

9.         Borran AA, Aghanejad A, Farajollahi A, Barar J, Omidi Y. Gold nanoparticles for radiosensitizing and imaging of cancer cells. Radiation Physics and Chemistry. 2018;152:137-44.

10.       Daryanoosh M, Goudarzi G, Rashidi R, Keishams F, Hopke PK, Mohammadi MJ, et al. Risk of morbidity attributed to ambient PM<inf>10</inf>in the western cities of Iran. Toxin Reviews. 2017:1-6.

11.       Dehghani J, Adibkia K, Movafeghi A, Barzegari A, Pourseif MM, Maleki Kakelar H, et al. Stable transformation of Spirulina (Arthrospira) platensis: a promising microalga for production of edible vaccines. Applied Microbiology and Biotechnology. 2018;102(21):9267-78.

12.       Eskandani M, Vandghanooni S, Barar J, Nazemiyeh H, Omidi Y. Cell physiology regulation by hypoxia inducible factor-1: Targeting oxygen-related nanomachineries of hypoxic cells. International Journal of Biological Macromolecules. 2017;99:46-62.

13.       Fahimi F, Sarhaddi S, Fouladi M, Samadi N, Sadeghi J, Golchin A, et al. Phage display-derived antibody fragments against conserved regions of VacA toxin of Helicobacter pylori. Applied Microbiology and Biotechnology. 2018;102(16):6899-913.

14.       Fahimi F, Tohidkia MR, Fouladi M, Aqabeigi R, Samadi N, Omidi Y. Pleiotropic cytotoxicity of VacA toxin in host cells and its impact on immunotherapy. BioImpacts. 2017;7(1):59-71.

15.       Fathi M, Majidi S, Zangabad PS, Barar J, Erfan-Niya H, Omidi Y. Chitosan-based multifunctional nanomedicines and theranostics for targeted therapy of cancer. Medicinal Research Reviews. 2018;38(6):2110-36.

16.       Fathi M, Sahandi Zangabad P, Barar J, Aghanejad A, Erfan-Niya H, Omidi Y. Thermo-sensitive chitosan copolymer-gold hybrid nanoparticles as a nanocarrier for delivery of erlotinib. International Journal of Biological Macromolecules. 2018;106:266-76.

17.       Fathi M, Zangabad PS, Aghanejad A, Barar J, Erfan-Niya H, Omidi Y. Folate-conjugated thermosensitive O-maleoyl modified chitosan micellar nanoparticles for targeted delivery of erlotinib. Carbohydrate Polymers. 2017;172:130-41.

18.       Fathi M, Zangabad PS, Majidi S, Barar J, Erfan-Niya H, Omidi Y. Stimuli-responsive chitosan-based nanocarriers for cancer therapy. BioImpacts. 2017;7(4):269-77.

19.       Ferdousi R, Safdari R, Omidi Y. Computational prediction of drug-drug interactions based on drugs functional similarities. Journal of Biomedical Informatics. 2017;70:54-64.

20.       Gharaati-Far N, Tohidkia MR, Dehnad A, Omidi Y. Efficiency and cytotoxicity analysis of cationic lipids-mediated gene transfection into AGS gastric cancer cells. Artificial Cells, Nanomedicine and Biotechnology. 2018;46(5):1001-8.

21.       Goudarzi G, Daryanoosh SM, Godini H, Hopke PK, Sicard P, De Marco A, et al. Health risk assessment of exposure to the Middle-Eastern Dust storms in the Iranian megacity of Kermanshah. Public Health. 2017;148:109-16.

22.       Jafarizad A, Aghanejad A, Sevim M, Metin Ö, Barar J, Omidi Y, et al. Gold Nanoparticles and Reduced Graphene Oxide-Gold Nanoparticle Composite Materials as Covalent Drug Delivery Systems for Breast Cancer Treatment. ChemistrySelect. 2017;2(23):6663-72.

23.       Karami P, Majidi MR, Johari-Ahar M, Barar J, Omidi Y. Development of screen-printed tryptophan-kynurenine immunosensor for in vitro assay of kynurenine-mediated immunosuppression effect of cancer cells on activated T-cells. Biosensors and Bioelectronics. 2017;92:287-93.

24.       Khajeh S, Tohidkia MR, Aghanejad A, Mehdipour T, Fathi F, Omidi Y. Phage display selection of fully human antibody fragments to inhibit growth-promoting effects of glycine-extended gastrin 17 on human colorectal cancer cells. Artificial Cells, Nanomedicine and Biotechnology. 2018:1-9.

25.       Maleki Kakelar H, Barzegari A, Dehghani J, Hanifian S, Saeedi N, Barar J, et al. Pathogenicity of Helicobacter pylori in cancer development and impacts of vaccination. Gastric Cancer. 2018.

26.       Mesgari-Shadi A, Sarrafzadeh MH, Barar J, Omidi Y. Cost-effective batch production process of scFv antibody in Escherichia coli. Human Antibodies. 2017;26(3):149-57.

27.       Mesgari-Shadi A, Sarrafzadeh MH, Divband B, Barar J, Omidi Y. Batch adsorption/desorption for purification of scFv antibodies using nanozeolite microspheres. Microporous and Mesoporous Materials. 2018;264:167-75.

28.       Mohammadi MJ, Yari AR, Saghazadeh M, Sobhanardakani S, Geravandi S, Afkar A, et al. A health risk assessment of heavy metals in people consuming Sohan in Qom, Iran. Toxin Reviews. 2017:1-9.

29.       Momtazan M, Geravandi S, Rastegarimehr B, Valipour A, Ranjbarzadeh A, Yari AR, et al. An investigation of particulate matter and relevant cardiovascular risks in Abadan and Khorramshahr in 2014–2016. Toxin Reviews. 2018:1-8.

30.       Nakhlband A, Eskandani M, Omidi Y, Saeedi N, Ghaffari S, Barar J, et al. Combating atherosclerosis with targeted nanomedicines: Recent advances and future prospective. BioImpacts. 2018;8(1):59-75.

31.       Nakhlband A, Eskandani M, Saeedi N, Ghafari S, Omidi Y, Barar J, et al. Marrubiin-loaded solid lipid nanoparticles’ impact on TNF-α treated umbilical vein endothelial cells: A study for cardioprotective effect. Colloids and Surfaces B: Biointerfaces. 2018;164:299-307.

32.       Neisi A, Albooghobeish M, Geravandi S, Adeli Behrooz HR, Mahboubi M, Omidi Khaniabad Y, et al. Investigation of health risk assessment sevoflurane on indoor air quality in the operation room in Ahvaz city, Iran. Toxin Reviews. 2018:1-9.

33.       Neisi A, Idani E, Vosoughi M, Hazrati S, Babaei AA, Takdastan A, et al. Answers to the comments on “Air pollution, biological marker and lung function in children”. Environmental Science and Pollution Research. 2018;25(27):27669-71.

34.       Nemati E, Azami A, Mokhtarzadeh A, Rahbar Saadat Y, Omidi Y, Ezzati Nazhad Dolatabadi J. Formulation and characterization of ethambutol loaded nanostructured lipid carrier. Latin American Journal of Pharmacy. 2017;36(2):247-52.

35.       Omidi Khaniabadi Y, Sicard P, Omidi Khaniabadi A, Mohammadinejad S, Keishams F, Takdastan A, et al. Air quality modeling for health risk assessment of ambient PM<inf>10</inf>, PM<inf>2.5</inf> and SO<inf>2</inf> in Iran. Human and Ecological Risk Assessment. 2018.

36.       Pakchin PS, Nakhjavani SA, Saber R, Ghanbari H, Omidi Y. Recent advances in simultaneous electrochemical multi-analyte sensing platforms. TrAC - Trends in Analytical Chemistry. 2017;92:32-41.

37.       Panahpour H, Farhoudi M, Omidi Y, Mahmoudi J. An in vivo assessment of blood-brain barrier disruption in a rat model of ischemic stroke. Journal of Visualized Experiments. 2018;2018(133).

38.       Parvizpour S, Razmara J, Omidi Y. Breast cancer vaccination comes to age: Impacts of bioinformatics. BioImpacts. 2018;8(3):223-35.

39.       Pourseif MM, Moghaddam G, Daghighkia H, Nematollahi A, Omidi Y. A novel B- and helper T-cell epitopes-based prophylactic vaccine against Echinococcus granulosus. BioImpacts. 2018;8(1):39-52.

40.       Pourseif MM, Moghaddam G, Naghili B, Saeedi N, Parvizpour S, Nematollahi A, et al. A novel in silico minigene vaccine based on CD4+ T-helper and B-cell epitopes of EG95 isolates for vaccination against cystic echinococcosis. Computational Biology and Chemistry. 2018;72:150-63.

41.       Pourseif MM, Moghaddam G, Saeedi N, Barzegari A, Dehghani J, Omidi Y. Current status and future prospective of vaccine development against Echinococcus granulosus. Biologicals : journal of the International Association of Biological Standardization. 2018;51:1-11.

42.       Rahmanian N, Eskandani M, Barar J, Omidi Y. Recent trends in targeted therapy of cancer using graphene oxide-modified multifunctional nanomedicines. Journal of Drug Targeting. 2017;25(3):202-15.

43.       Ranjbar-Navazi Z, Eskandani M, Johari-Ahar M, Nemati A, Akbari H, Davaran S, et al. Doxorubicin-conjugated D-glucosamine- and folate- bi-functionalised InP/ZnS quantum dots for cancer cells imaging and therapy. Journal of Drug Targeting. 2018;26(3):267-77.

44.       Rodriguez-Ruiz V, Salatti-Dorado JÁ, Barzegari A, Nicolas-Boluda A, Houaoui A, Caballo C, et al. Astaxanthin-loaded nanostructured lipid carriers for preservation of antioxidant activity. Molecules. 2018;23(10).

45.       Salmanzadeh R, Eskandani M, Mokhtarzadeh A, Vandghanooni S, Ilghami R, Maleki H, et al. Propyl gallate (PG) and tert-butylhydroquinone (TBHQ) may alter the potential anti-cancer behavior of probiotics. Food Bioscience. 2018;24:37-45.

46.       Samadi Pakchin P, Ghanbari H, Saber R, Omidi Y. Electrochemical immunosensor based on chitosan-gold nanoparticle/carbon nanotube as a platform and lactate oxidase as a label for detection of CA125 oncomarker. Biosensors and Bioelectronics. 2018;122:68-74.

47.       Shakoori Z, Ghanbari H, Omidi Y, Pashaiasl M, Akbarzadeh A, Jomeh Farsangi Z, et al. Fluorescent multi-responsive cross-linked P(N-isopropylacrylamide)-based nanocomposites for cisplatin delivery. Drug Development and Industrial Pharmacy. 2017;43(8):1283-91.

48.       Tohidkia MR, Sepehri M, Khajeh S, Barar J, Omidi Y. Improved Soluble ScFv ELISA Screening Approach for Antibody Discovery Using Phage Display Technology. SLAS Discovery. 2017;22(8):1026-34.

49.       Vandghanooni S, Eskandani M, Barar J, Omidi Y. AS1411 aptamer-decorated cisplatin-loaded poly(lactic-co-glycolic acid) nanoparticles for targeted therapy of miR-21-inhibited ovarian cancer cells. Nanomedicine. 2018;13(21).

50.       Vandghanooni S, Eskandani M, Barar J, Omidi Y. Bispecific therapeutic aptamers for targeted therapy of cancer: a review on cellular perspective. Journal of Molecular Medicine. 2018;96(9):885-902.

51.       Vandghanooni S, Eskandani M, Barar J, Omidi Y. Recent advances in aptamer-armed multimodal theranostic nanosystems for imaging and targeted therapy of cancer. European Journal of Pharmaceutical Sciences. 2018;117:301-12.

52.       Zamanlu M, Farhoudi M, Eskandani M, Mahmoudi J, Barar J, Rafi M, et al. Recent advances in targeted delivery of tissue plasminogen activator for enhanced thrombolysis in ischaemic stroke. Journal of Drug Targeting. 2018;26(2):95-109.

53.       Zeydouni G, Kianizadeh M, Omidi Khaniabadi Y, Nourmoradi H, Esmaeili S, Mohammadi MJ, et al. Eriochrme black-T removal from aqueous environment by surfactant modified clay: equilibrium, kinetic, isotherm, and thermodynamic studies. Toxin Reviews. 2018:1-11.

54.       Zeydouni G, Rodriguez Couto S, Nourmoradi H, Basiri H, Amoatey P, Esmaeili S, et al. H<inf>2</inf>SO<inf>4</inf>-modified Aloe vera leaf shells for the removal of P-chlorophenol and methylene blue from aqueous environment. Toxin Reviews. 2018:1-11.

55.       Zununi Vahed S, Barzegari A, Rahbar Saadat Y, Goreyshi A, Omidi Y. Leuconostoc
mesenteroides-derived anticancer pharmaceuticals hinder inflammation and cell survival in colon cancer cells by modulating NF-κB/AKT/PTEN/MAPK pathways. Biomedicine and Pharmacotherapy. 2017;94:1094-100.

56.       Zununi Vahed S, Moghaddas Sani H, Rahbar Saadat Y, Barzegari A, Omidi Y. Type 1 diabetes: Through the lens of human genome and metagenome interplay. Biomedicine and Pharmacotherapy. 2018;104:332-42.

57.       Zununi Vahed S, Omidi Y, Ardalan M, Samadi N. Dysregulation of urinary miR-21 and miR-200b associated with interstitial fibrosis and tubular atrophy (IFTA) in renal transplant recipients. Clinical Biochemistry. 2017;50(1-2):32-9.

58.       Zununi Vahed S, Poursadegh Zonouzi A, Ghanbarian H, Ghojazadeh M, Samadi N, Omidi Y, et al. Differential expression of circulating miR-21, miR-142-3p and miR-155 in renal transplant recipients with impaired graft function. International Urology and Nephrology. 2017;49(9):1681-9.

59.       Zununi Vahed S, Poursadegh Zonouzi A, Mahmoodpoor F, Samadi N, Ardalan M, Omidi Y. Circulating miR-150, miR-192, miR-200b, and miR-423-3p as Non-invasive Biomarkers of Chronic Allograft Dysfunction. Archives of Medical Research. 2017;48(1):96-104.

60.       Fakhari A, Aghanejad A, Jalilian AR, Gharepapagh E. Recent developments in targeted imaging of CXCR4-chemokine receptor. Journal of Radioanalytical and Nuclear Chemistry. 2018;317(1).

61.       Abbasian M, Roudi MM, Mahmoodzadeh F, Eskandani M, Jaymand M. Chitosan-grafted-poly(methacrylic acid)/graphene oxide nanocomposite as a pH-responsive de novo cancer chemotherapy nanosystem. International Journal of Biological Macromolecules. 2018;118:1871-9.

62.       Ahani N, Sangtarash MH, Houshmand M, Eskandani MA. Genipin induces cell death via intrinsic apoptosis pathways in human glioblastoma cells. Journal of Cellular Biochemistry. 2018.

63.       Ahmadi R, Eskandani MA, Saadati D. Evaluation of antimicrobial effect of Iranian sumac on Bacillus cereus in a commercial barley soup. Slovenian Veterinary Research. 2017;54(2):65-9.

64.       Alizadeh N, Eskandani M, Tondro K, Rashidi MR, Nazemiyeh H. Inhibitory effects of flavonolignans from silybum marianum (L.) gaertn (milk thistle) on function of aldehyde oxidase and xanthine oxidase in rats. Letters in Drug Design and Discovery. 2018;15(3):256-62.

65.       Anvari D, Saadati D, Nabavi R, Alipour Eskandani M. Epidemiology and molecular prevalence of Toxoplasma gondii in cattle Slaughtered in Zahedan and Zabol Districts, South East of Iran. Iranian Journal of Parasitology. 2018;13(1):114-9.

66.       Bahadori MB, Eskandani M, De Mieri M, Hamburger M, Nazemiyeh H. Anti-proliferative activity-guided isolation of clerodermic acid from Salvia nemorosa L.: Geno/cytotoxicity and hypoxia-mediated mechanism of action. Food and Chemical Toxicology. 2018;120:155-63.

67.       Hamishehkar H, Bahadori MB, Vandghanooni S, Eskandani M, Nakhlband A, Eskandani M. Preparation, characterization and anti-proliferative effects of sclareol-loaded solid lipid nanoparticles on A549 human lung epithelial cancer cells. Journal of Drug Delivery Science and Technology. 2018;45:272-80.

68.       Jafarizad A, Taghizadehgh-Alehjougi A, Eskandani M, Hatamzadeh M, Abbasian M, Mohammad-Rezaei R, et al. PEGylated graphene oxide/Fe<inf>3</inf>O<inf>4</inf>site: Synthesis, characterization, and evaluation of its performance as de novo drug delivery nanosystem. Bio-Medical Materials and Engineering. 2018;29(2):177-90.

69.       Nazemi K, Salari S, Eskandani MA. Assessment of the escherichia coli pollution in drinking water and water sources in sistan, iran. Journal of Water Reuse and Desalination. 2018;8(3):386-92.

70.       Soleymani J, Hasanzadeh M, Eskandani M, Khoubnasabjafari M, Shadjou N, Jouyban A. Electrochemical sensing of doxorubicin in unprocessed whole blood, cell lysate, and human plasma samples using thin film of poly-arginine modified glassy carbon electrode. Materials Science and Engineering C. 2017;77:790-802.

71.       Zamanlu M, Eskandani M, Mohammadian R, Entekhabi N, Rafi M, Farhoudi M. Spectrophotometric analysis of thrombolytic activity: SATA assay. BioImpacts. 2018;8(1):31-8.